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IGF-1R is linked to various cytoplasmic second messenger molecules including the RAS-MAPK and PI3K signalling networks

They participated in the concept of the study, doing the whole literature review, data extraction, and writing the different sections of the manuscript

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Glutathione is a major player in the immune system, while NAD+ provides the energy required for cellular repair

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However, current evidence is primarily derived from in vitro models or animal studies, and often relies on indirect indicators such as protein expression changes (e.g., LC3-II, Beclin-1)