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In the present post hoc analysis published in Diabetes Care , Klein and colleagues examined data on the 16 996 adults participating in four large randomised, double-blind, placebo-controlled clinical trials assessing the safety and efficacy of GLP-1 RAs: the LEADER trial of liraglutide, the STEP 2 and SUSTAIN 6 trials of subcutaneous semaglutide, and the PIONEER 6 trial of oral semaglutide

Shaw C, Hess M, Weimer BC (2023) Microbial-derived tryptophan metabolites and their role in neurological disease: anthranilic acid and anthranilic acid derivatives

Severe nausea, inability to keep food down, signs of dehydration, or persistent abdominal pain warrant immediate medical evaluation to rule out acute complications

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The thought of reconstituting peptides with bacteriostatic water , calculating doses, and self-administering subcutaneous injections feels overwhelming