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Special thanks to my co-first author Katherine and to Cristina, whose support and guidance were instrumental throughout this work

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An overdose is recognizable by the following signs: Shallow breathing, slow breathing or respiratory failure Small pupils Confusion Unresponsiveness or loss of consciousness Blue skin due to poor circulation In the case of an opioid overdose emergency, call 911 immediately

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Although in vitro studies of the injured peripheral nerve suggest a role in neuronal regeneration, neurotrophinsBDNF and N/T-4/5 in particularhave the ability to bind both growth-promoting and growth-inhibiting receptors

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