compound glp 1 vs zepbound FDA Ends Compounded GLP-1s: What to Know GLP-1s and Peptide Therapies: What

Some portion of intranasally administered peptides may reach the brain through the olfactory pathway, bypassing the blood-brain barrier that limits systemic delivery to CNS tissues

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Injured by GLP-1 Drugs

This doesn't mean it's unsafe it means it hasn't gone through the specific regulatory pathway the FDA requires for approved drugs

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However, the role of p53 in regulation of IGF-1R seems to be more complex and probably also involves post-transcriptional mechanisms (Girnita et al, 2000