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While all GLP-1 receptor agonists effectively lower hemoglobin A1c and promote weight loss, there are meaningful differences in their magnitude of effect, titration schedules, and adverse effect profiles that influence clinical decision-making

These drugs produce weight loss results previously only seen in bariatric surgery 15-20% average weight loss

Many neuroprotective effects remain to be causally associated with anti-inflammatory mechanisms, and some Alzheimers disease mouse models did not respond to semaglutide or tirzepatide, emphasizing that not all neural benefits are consistent across studies

Side effects I also really became *not* hungry at all when I physically felt hunger

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The most common reported side effects are gastrointestinal, especially nausea, diarrhea, constipation, and vomiting