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In line with these observations, the treatment of the murine syngeneic PCa and bladder cancer models with the JHU-083 inhibitor led to the reprogramming of the tumor-associated macrophages (TAMs) from an immunosuppressive to inflammatory state and increased TAM proliferation and glycolysis [99]

doi: 10.1016/j.biotechadv.2016.11.004 75 SadikR.AbrahamssonH.UngK

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