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This is due to the bacteriostatic agent, usually benzyl alcohol, that inhibits the growth of bacteria in the vial
Oxidative stress-induced mitochondrial impairment and glutathione (GSH) depletion are considered pivotal drivers of hepatocyte apoptosis and necrosis (Hinson et al., 2009), processes further exacerbated by the infiltration of inflammatory cells and the overproduction of pro-inflammatory cytokines such as TNF- , IL-1 , IL-6 , and IL-8 , alongside anti-inflammatory mediators like IL-10 (Hinson et al., 2009)
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Moreover, data from clinical evidence have shown that tocopherols and tocotrienols supplementation in Alzheimer's patients reduces lipid peroxidation by up to 60% compared with that of the control (Morris et al., 2005)
(PubMed) Abramovici A, Gandley RE, Clifton RG, et al
