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At the same time, more of your existing NAD+ gets consumed by enzymes like CD38 and PARPs, which are activated by things like inflammation, oxidative stress, and DNA damage
This effect is believed to come from B12s support of neurotransmitters such as serotonin and dopamine, which influence cognitive function and emotional balance
While B12 can be saved for your liver for as much as 5 years, you can become deficient in it in case you do not get enough
Some people, however, struggle to maintain adequate levels of this vitamin due to various factors such as diet, absorption issues, or certain medical conditions