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Hashimoto disease is an autoimmune disorder that may cause 30% to 90% of hypothyroidism cases, making it the most common cause of thyroid disease in the US, according to the American Thyroid Association

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Combinations such as paclitaxelcarboplatin for ovarian carcinoma, BEP (bleomycinetoposidecisplatin) for germ-cell tumours and CHOP (cyclophosphamidedoxorubicinvincristineprednisone) for lymphomas thus expose the ovary to synergistic genotoxic stress

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