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Nnc-260161 6
Additionally, it negatively affects the activity of energy metabolism-related neurons in the hypothalamic arcuate nucleus (e.g., increases appetite and energy intake by elevating spiny mouse state-related protein: agouti related protein (AgRP) neurons and decreasing levels of allantoinogen proopiomelanocortin (POMC) neurons)
Reported side effects are uncommon and typically mild: Localized redness, swelling, or irritation at the injection site
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In an attempt to gain molecular insight, PNPO mutations frequently seen in patients with neonatal epileptic encephalopathy were introduced into Chinese hamster ovary cells, and PNPO activities and subsequent PLP synthesis both declined [190,191], suggesting PNPO-mediated disruption of vitamin B6 synthesis