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The top 10 significantly enriched pathways include Glycerophospholipid metabolism, Choline metabolism in cancer, Insulin signaling pathway in cancer, Glycolysis/Gluconeogenesis, Central carbon metabolism in cancer, Alanine, aspartate and glutamate metabolism, Niacin and Niacinamide metabolism, -Alanine metabolism, Insulin resistance, and the AMPK (AMP-activated protein kinase) signaling pathway (Figure 5B)

HR-L: Validation, Writing review & editing

Sodium, potassium, and magnesium losses accelerate with frequent loose stools, and replacing these minerals helps restore normal bowel function

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Interatomic contacts and hydrogen bonds were detected using the GetContacts scripts tool ( setting a hydrogen bond donor-acceptor distance of 3.3 and an angle value of 120 as geometrical cut-offs