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In vitamin B12 deficiency, the enzymes methionine synthase (in the homocysteine pathway) and methylmalonyl-CoA mutase (in the MMA pathway) are impaired because they depend on B12

The condition is characterized by the dying back of distal sensory axons in a length-dependent manner, presenting as a stocking and glove pattern of sensory loss

EC 3.1.1.79) play important roles in this regulation [114]

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As research on transcription and translation advanced, it was discovered that initial RNA transcripts typically require intron removal and the linkage of exons to form mature messenger RNA (mRNA), a process known as RNA splicing

Others resort to compounded forms from licensed pharmacies to make it less expensive