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Acknowledgements This work was supported by a project grant from the Dutch Cancer Society (# 10212) to C.R.J

Practice recommendations for the use of L-carnitine in dialysis-related carnitine disorder

IC 50 = half-maximal inhibitory concentration

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Supresa Saffron Extract: Standardized to 0.3% safranal, this extract has been associated with a 69% decrease in hunger and a 55% reduction in snacking events over an eight-week period

2 Materials and methods 2.1 Materials and reagents L-Carnosine, lipopolysaccharides, and papain were purchased from MCE (New Jersey, United States)