Clinical trials show tirzepatide produces slightly greater average weight loss (around 2022%) compared to semaglutide (around 1417%) in similar populations
The decision to initiate SGLT2i and GLP-1RA concurrently should be individualized or possibly spread apart in time, weighing the potential therapeutic benefits against the risk of rare but severe complication such as euDKA
Sohal, D
Comparative example 3 Referring to the patent CN113801233A, fmoc-His-Aib-OH dipeptide was used instead of Boc-His (Trt) -Aib-OH dipeptide in the present invention, and GLP- (9-37) requires Boc protection of the amino group of Lys in advance
FDA staff also noted that no adequate studies formally evaluated immunogenicity
The problem with that is, the counterpoint to chaos is predictability, and when it comes to things like industry having the faith to invest in innovative, expensive therapeutic programs, they want predictability relative to how the regulatory process is going to work