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The SURPASS-2 trial (N=1,879), published in the New England Journal of Medicine in 2021, used exactly this 4-week step schedule and still reported GI adverse events as the most common reason for discontinuation [3]

Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial

of this final rule with comment period, we finalized the adoption of the Emergency Care Access & Timeliness eCQM beginning with voluntary reporting for the CY 2027 reporting period followed by mandatory reporting beginning with the CY 2028 reporting period/CY 2030 payment determination

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10.15252/msb.20167422 Mol Syst Biol

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