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Aging Cell 3(6):399411

Pure GLP-1 receptor agonists work through four mechanisms: Slowed gastric emptying (the primary satiety signal) Increased insulin secretion in response to glucose Reduced glucagon secretion (glucagon raises blood sugar) Central appetite suppression via hypothalamic GLP-1 receptors The weight loss ceiling for pure GLP-1 agonists appears to be around 15% to 17% of baseline body weight at maximum tolerated dose over 68 weeks (the STEP 1 and STEP 5 trial endpoints for semaglutide 2.4 mg)

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10.14336/AD.2019.0510 Aging Dis

Se estima que entre el 20% y el 50% del peso perdido con estos frmacos puede provenir de masa magra si no se interviene adecuadamente, segn un estudio liderado por Melanie Haines, M.D., del Massachusetts General Hospital y la Harvard Medical School en Boston

Stem cells, endothelial cells, and various repair cells can migrate more effectively toward damaged tissue through a process called chemotaxis