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also indicated that, compared to other antidiabetic drugs, DPP-4 inhibitors led to an increased number of reports of gallbladder or biliary diseases, with sitagliptin accounting for up to 80% of the cases ( For GLP-1 RAs, our results indicated that although it did not show a direct correlation with biliary diseases overall, specific drugs such as semaglutide [ROR 4.06

During heart tube assembly, the endoderm mechanical role is critical as it contracts, pulling the heart fields towards the midline to facilitate heart tube formation

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They may experience chemical degradation, conformational changes, or formulation-related instability over time

doi: 10.1016/j.jpba.2025.116682 Lee G