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Astrocytes in ALS show many signs of functional decline, for example they demonstrate abnormal Ca 2+ signalling, 573 impaired secretion of neuroprotective glial-derived neurotrophic factor, 574 as well as reduced lactate production

Arzneim Forsch Drug Res 42:211214 Moreno L, Martnez-Cuesta MA, Muedra V, Beltrn B, Esplugues J (1997) Role of the endothelium in the relaxation induced by propofol and thiopental in isolated arteries from man

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A strain with an add (encoding adenosine deaminase) mutation showed enhanced GSH production

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Helps to regulate the biological and circadian rhythm