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These diseases are associated with the excessive accumulation of ROS, which induces oxidative damage to macromolecules and impairs cellular function, thereby contributing to their pathogenesis

doi: 10.1016/0002-9149(95)80016-L

Bernink FJ, Timmers L, Diamant M, et al

Because Melanotan II works within the broader melanocortin system, MC1R variation may influence related signaling, though its main well-known role remains pigmentation

They also demonstrated that increased antioxidant enzyme activity may benefit HIV patients, with antioxidant supplementation reducing lipid peroxidation

Food Research International, 169, 112890