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As both IBD and PD have compromised intestinal barrier functions, DJ-1 deficiency promotes cytokine-mediated inflammation (IL-1, IL-6, TNF, and TGFB1) and apoptosis of intestinal epithelial cells via a p53-dependent mechanism in vitro , in ex vivo colonic sacs, and in vivo (van IJzendoorn and Derkinderen, 2019

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Experientia 37:913917

During the early stages of acute pancreatitis, the inflammatory response damages the intestinal barrier, allowing bacteria and endotoxins to enter the blood, triggering an inflammatory storm, sepsis, and even multiple organ failure [92]

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Full Text (PMC) Stable Gastric Pentadecapeptide BPC 157, Robert's Stomach Cytoprotection/Adaptive Cytoprotection Revisited