Reason #1: Your Dose Might Still Be Too Low Semaglutide is prescribed at a low starting dose to minimize side effects like nausea or fatigue
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While they share a common mechanismmimicking the GLP-1 hormone to stimulate insulin secretion, suppress glucagon release, and slow gastric emptyingthey differ in their molecular structures, dosing schedules, efficacy, and side effect profiles
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The glucagon component, in particular, adds effects that semaglutide and tirzepatide users do not experience, including increased thermogenesis and changes in hepatic glucose output