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QUE undergoes extensive metabolic transformation in the body, primarily in the enterocytes and liver, leading to the formation of numerous metabolites

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Molecular and Cellular Endocrinology, 331 (1), 3440

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The hepatitis C virus (HCV) is an enveloped virus with a single stranded, positive sense, nonsegmented RNA genome of approximately 9,500 nucleotides that encodes a polyprotein of approximately 3,000 amino acids (1,2)