These findings suggest that PYC may exert its immunomodulatory effects through coordinated suppression of TLR4-mediated NF-B signaling, although further studies are needed to clarify the underlying molecular mechanisms
Antioxidants 12:731
In accordance with our results, Saito et al
Ishii H, Aoyama T, Takahashi H, et al
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Furthermore, the depletion of arginine restrains Oxphos in the mitochondria, after epigenetic changes (i.e., reduced histone acetylation due to a restricted pool of acetyl-CoA) in tumor cells (breast cancer), impairing tumor development