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Genetic deletion of A(2A) adenosine receptors in the striatum selectively impairs habit formation

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Will the addition of IGF-1 agonism confer extra glycemic stability or beta-cell protection

Subject to approval

Insulin interacts with its receptor on -cells to inhibit exocytosis through PI3KAktdependent pathways ( A comprehensive summary of these regulatory mechanisms, including upstream stimuli, receptor pathways, intracellular kinases, and their overall effects on -cell glucagon secretion, is provided in Table 1 and Figure 1