This molecule, as well as the broader pipeline, placed Metsera at the centre of a fierce bidding war between Pfizer and Novo Nordisk in late 2025, with an eventual deal value of around ~US$10bn
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The results of immunostaining and western blot showed that an obvious increased protein expression of 4-HNE was found in peroxynitrite treated SGNs, while it was significantly decreased in peroxynitrite + ebselen group but further increased in peroxynitrite + gpx1 / mice compared with the peroxynitrite-only group (Figures 5B,C)
Disulfide-containing high mobility group box-1 promotes N-Methyl-d-Aspartate receptor function and excitotoxicity by activating toll-like receptor 4-dependent signaling in hippocampal neurons
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