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Most evidence is derived from small trials, cell culture studies, and animal models rather than large randomized controlled trials

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370,371 Ongoing research aims to identify safe and effective autophagy modulators as potential therapeutic strategies for DPN

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10.3390/biomedicines9080992 153 KimJ.-Y.KimK.-H.LeeW.-R.AnH.-J.LeeS.-J.HanS.-M.et al (2015a)

Additionally, the aberrant muscularization of distal arterioles and excessive production of reactive oxygen species (ROS) exacerbate disease progression by promoting inflammation, oxidative stress, and cellular proliferation (Freund-Michel et al., 2013