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An animal model of chronic migraine demonstrated a decrease in nicotinic acetylcholine receptors and an increase in inflammatory astrocytes and proteins 43

In mice, a high-fat diet has also been shown to impair leptin signaling by attenuating STAT3 activation, thus contributing to leptin resistance [18].Leptin receptor activation engages intracellular proteins, such as protein tyrosine phosphatase1 B (PTP1B) and suppressor of cytokine signaling-3, that terminate receptor signaling

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Immunofluorescence tissues were mounted with Immuno-Mount (Thermo Fisher, 9990402) and coverslipped for imaging

Water cities such as coastal territories, river cities and delta regions are particularly vulnerable to the effects of climate extremes which are pushing public authorities to identify adaptive interventions across scales and time