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With a high dietary supply of methionine-rich animal proteins, an increase in tissue concentrations of SAM occurs, and 70% of homocysteine is catabolized by CBS through the transsulfuration pathway (Fig

90,91 Moreover, in both human and hamster models, this inflammation, cytokine expression, and BBB disruption can lead to the disruption of neurogenesis and contribute to neuronal dysfunction and loss which ultimately leads to neuronal PACS symptoms

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Reviews referencing personal health outcomes are summarized editorially