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126,127 Familial genetic mutations and polymorphisms can also alter astrocyte functions in ways that contribute to disorder progression as noted in Huntingtons disease, 117,128 familial amyotrophic lateral sclerosis (ALS) mutations, 129,130 or familial AD mutations

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594 Transferrin, high mobility group protein 1 (HMGB1), and CP are ferroptosis-related factors associated with PD in the substantia nigra