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The hydroxylated products are markedly more water-soluble than their precursors and are much more readily excreted from the body

Hirose T, Sumitomo M, Kudo E, Hasegawa T, Teramae T, Murase M, Higasa Y, Ikata T, Hizawa K: Malignant peripheral nerve sheath tumor (MPNST) showing perineurial cell differentiation

Expiration dates include a safety margin

doi: 10.1038/s41387-022-00209-z 33

It is important to understand that the key players evaluating their novel therapies in the pivotal and confirmatory trials should remain vigilant when selecting appropriate comparators to stand the greatest chance of a positive opinion from regulatory bodies, leading to approval, smooth launch, and rapid uptake