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Abbreviation PI Paralytic ileus T2D Type 2 diabetes GLP-1RAs Glucagon-like peptide-1 receptor agonists MR Mendelian randomization GWAS Genome-wide association studies SGLT-2 Sodium-glucose cotransporter-2 HbA1c hemoglobin A1C GTEx Genotype-Tissue Expression IVW Inverse-variance weighted GRCh37 Genome Reference Consortium Human Build 37 Chr Chromosome EA Effect Allele NEA Non-Effect Allele NES Normalized Effect Size SE Standard Error OR Odds ratio LD Linkage Disequilibrium Footnotes Declarations The authors declare that they have no conflict of interest
Importantly, localized increases in GLP-1, such as that occur in the gut and portal vein, often have a more profound effect than systemic elevations, emphasizing the therapeutic potential of targeting regional activity rather than relying solely on systemic concentrations
Significant levels of liraglutide were found in the brain of mice 30 minutes and 3 hours after intraperitoneal injection, indicating that liraglutide could cross the BBB (125)
Prioritizing protein intake at 0.7 to 1.0 grams per pound of body weight, staying well hydrated, exercising consistently with an emphasis on resistance training, sleeping seven to nine hours nightly, and managing stress all meaningfully accelerate results
Noteworthily, we observed that long-acting GLP-1 RAs offer more pronounced benefits, potentially due to their sustained pharmacological action, suggesting a dependency on pharmacokinetic profiles for maximal therapeutic impact
