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In summary, we showed that EPAC regulates primary melanoma growth through multiple mechanisms involving (i) RAP1GTP-mediated regulation of mitochondrial ROS production, (ii) mTORC1-mediated protein translation, cellular metabolism and cell cycle progression, and (iii) mTORC1-HIF1-mediated regulation of TXNIP/TRX, a critical regulator of redox homeostasis

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Having multiple locations helps Soboba serve a broader range of patients while still keeping care local and accessible

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Counsel on effective contraception if pregnancy is not desired