Progressive Dosing Protocols Rather than maintaining a static dose throughout a research cycle, progressive protocols involve systematic dose adjustments: Weeks 1-2 : Start at 15mg daily to assess baseline tolerance and response Weeks 3-4 : Increase to 25mg daily if well-tolerated Weeks 5-8 : Potentially increase to 30-35mg based on goals and response Weeks 9-12 : Maintain optimal dose identified during earlier weeks This approach allows for individualized optimization while maintaining safety margins
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avoid unnecessary calcium if constipation appears
Overall, most of the studies identified were conducted individually in continental countries such as Brazil, Chile, Argentina, Mxico, Ecuador and Colombia, which have a lower proportion of African ancestry compared to island nations like Haiti or The Bahamas ( Figure 1 )
doi: 10.3389/fendo.2025.1575087, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 148