The study found that triglycerides cross the blood-brain barrier and can induce leptin resistance.[ref open access] Theoretically, it makes sense that high triglycerides would block the leptin signal in times of starvation, driving people to need more food
Some people adjust over time, while others need changes to make treatment easier to tolerate
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As NAD+ supplementation research has expanded dramatically, the discovery that NNMT depletes NAD+ precursors specifically in metabolically dysfunctional fat tissue provides a targeted intervention point
Dose increases continue in 2.5 mg increments (up to 15 mg) every 4 weeks based on your response and tolerability