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Currently in Phase 3 clinical trials and not yet FDA-approved, retatrutide is studied for its ability to amplify energy expenditure beyond what single or dual agonists achieve

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Glossary CKD Chronic kidney disease CVD Cardiovascular disease FDA Food and Drug Administration GLP-1 Glucagon-like peptide-1 GLP-1s Glucagon-like peptide-1 receptor agonists HF Heart failure MASH Metabolic dysfunction-associated steatohepatitis OA Osteoarthritis OSA Obstructive sleep apnea PAD Peripheral arterial disease SC Subcutaneous T2DM Type 2 diabetes mellitus U.S

Further research by Malfatti et al