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Heres how different groups responded to treatment: Race and Ethnicity : Clinical benefits were consistent across all racial and ethnic groups Type 2 Diabetes : Patients without diabetes achieved higher total body weight loss (16.9%) versus those with diabetes (9.9%) at 12 months Body Mass Index (BMI) : After two years of treatment, 52.4% of participants moved down at least one BMI category Results show that 12% of adults receiving semaglutide reached a healthy BMI of 25 kg/m or less, compared to only 1.2% in the placebo group

Marketed under the brand names Mounjaro (for diabetes) and Zepbound (for weight management in adults with BMI 30 kg/m or 27 kg/m with at least one weight-related comorbidity), tirzepatide represents the first dual incretin receptor agonist available in clinical practice

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Minimal occurrence of side reaction such as aspartimide formation or racemization was observed, attributable to careful control of base concentration and coupling times

[Abstract]2026 May 6;74(17):13876-13886