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* Based on the trial product estimand: estimated efficacy in an idealized scenario in which all patients stayed on treatment and took no other weight loss therapies ** Based on the treatment policy estimand: estimated efficacy regardless of whether patients stayed on treatment or took other weight loss therapies About CagriSema CagriSema is being investigated by Novo Nordisk as a once-weekly subcutaneous injectable treatment for adults with overweight or obesity (REDEFINE program) and as a treatment for adults with type 2 diabetes (REIMAGINE program)

Golestaneh N, Chu Y, Xiao YY, Stoleru GL, Theos AC

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106,107 Unlike siRNA-mediated gene silencing, miRNAs can simultaneously recognize and regulate the expression of multiple target mRNAs due to their low complementarity