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Co-authored by Barbie Ritzman and Sophie Burkholder, BA This article was co-authored by Barbie Ritzman and by wikiHow staff writer, Sophie Burkholder, BA

Secondary pharmacokinetic endpoints included C max , time to reach C max following drug administration ( t max ), t , and apparent total clearance of the drug from plasma after subcutaneous administration (CL/ F )

Most trials showing benefit used multi-strain formulations alongside caloric restriction, making it difficult to isolate probiotic effects

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