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Acetazolamide can significantly reduce Hct and serum EPO levels in CMS patients, while simultaneously improving nocturnal oxygen saturation, decreasing the frequency of apnea-hypopnea episodes, and lowering pulmonary vascular resistance

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

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