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Overlapping two GLP-1 class drugs produces additive GI side effects that can be severe enough to require medical attention

In contrast, long-acting agents appear to have a larger effect on lowering fasting glucose due to their effect to increase insulin release and inhibit glucagon release (Meier 2012)

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At 48 weeks, the high-dose combination (bimagrumab 30 mg/kg + semaglutide 2.4 mg) achieved a mean weight reduction of 17.8 kg, exceeding semaglutide alone (14.2 kg)

Saving on Costs Even with insurance, GLP-1 drugs can be expensive