Weinstock RS, DuBose SN, Bergenstal RM, Chaytor NS, Peterson C, Olson BA, et al
The most effective sites are the deltoid (upper arm), thigh, or buttocks always administered by a trained healthcare provider
ACS Chemical Biology
In a randomized, placebo-controlled intervention study with more than 900 older participants experiencing psychological distress, daily supplementation with folic acid (400 g) and vitamin B 12 (100 g) for two years did not reduce the occurrence of symptoms of depression despite significantly improving blood folate, vitamin B 12 , and homocysteine levels compared to placebo (109)
Localized vs
Kannengiesser and colleagues (2008) independently confirmed anti-inflammatory potential in two distinct murine IBD models, reducing colonic damage and inflammatory cytokine levels with the melanocortin-derived tripeptide