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Do not schedule demanding tasks or make important decisions if you are feeling unusually tired

A 2020 study in Diabetes Care found that evening insulin sensitivity was 45% lower than morning sensitivity in healthy adults, and this gap widened to 60% in individuals with impaired glucose tolerance

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Elevating GH and downstream IGF-1 also carries broader theoretical concerns including effects on insulin sensitivity and glucose metabolism, and the general caution that any growth-promoting signal warrants care in anyone with a history of, or predisposition to, cancer

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