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Oral supplementation: In some cases, where the deficiency is mild or once injection therapy has been completed, oral B12 supplements may be used for maintenance

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FOXO4-DRI has been investigated extensively in preclinical academic literature for p53 transactivation domain binding, senescence-associated apoptosis pathway research, p16 and IL-6 marker dynamics in senescent cell research models, and SASP (senescence-associated secretory phenotype) signaling