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Prolonged inflammation can trigger a positive feedback loop, exacerbating symptoms of demyelinating diseases such as cognitive and motor impairments ( 2.5 Efferocytosis can alleviate inflammatory responses through interactions with specialized pro-resolving mediators (SPMs) The -oxidation of fatty acids from apoptotic cells within the mitochondria leads to the production of NAD + and complex III subunit 5, which in turn activate the transcription factor PBX1

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Moreover, peroxidative ROS levels depend on the caution of the antioxidant systems, which shield cells from oxidative harm, incorporate various peroxisomal enzymes, such as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPX), and peroxiredoxins (PRDX), as well as low molecular weight non-enzymatic antioxidants [17]

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