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The distinction between malignant and benign phenotypes was established by the presence of lower levels of free cysteine in the plasma of women with benign tumours

Loss of SLC25A39 reduces mitochondrial GSH import and abundance without affecting cellular GSH levels

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However, phenobarbital and TCDD are also phase II enzyme inducers with induction of some glutathione transferases and UDP-glucuronyltransferases in centrilobular hepatocytes and predominant periportal expression of glutathione peroxidase (Lindros 1997)