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If a step provokes strong GI symptoms, the documented approach is to hold at the current dose (or step back down) rather than push forward on the calendar

Self-directed combination therapy is strongly discouraged due to safety concerns

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The strategies for treating Alzheimers disease: Insulin signaling may be a feasible target

doi: 10.1016/j.bbr.2018.08.006 Summary Keywords Alzheimers disease, GLP-1R agonists, cognitive function, amyloid beta, tau phosphorylation Citation Du H, Meng X, Yao Y and Xu J (2022) The mechanism and efficacy of GLP-1 receptor agonists in the treatment of Alzheimers disease