Most common side effects were gastrointestinal, with 24.5% of participants in the phase 2 obesity trial discontinuing efinopegdutide 10 mg due to AE however when the same dose was used with gradual escalation at the MASLD trial (starting dose 2.4 mg for 4 weeks, then 5 mg for 4 weeks and then 10 mg), only 5.6% of participants discontinued the medication due to AE
4g and Supplementary Fig
We were interested in finding which drug gives the most weight loss and doesnt have higher rates of side effects like nausea and gastrointestinal problems
In addition, while most group health plans (whether fully insured or self-funded) are subject to many federal laws, including the preventive-care mandates under the Affordable Care Act (learn more here), none require employers to cover GLP-1 drugs for either diabetes treatment or weight loss
Employers have largely attempted to avoid these cost increases, with a 2023 Accolade survey finding that approximately 60% of employers do not intend to cover GLP-1s in 2024
Psychological changes differ across people while falling into eight general categories