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[1] [2] Treatment intensification should follow a stepwise approach , typically starting with metformin and adding further agents based on individual patient factors such as HbA1c levels, cardiovascular risk, renal function, and patient preference

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IP3 promotes intracellular calcium release, further activating ERK (75), while DAG activates protein kinase C (PKC), which directly phosphorylates and activates C-Raf (76,77)

For now, the point of Bet 1 is defensive: dont let the competitor own the diabetes prescription pad

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Obesity and depression often have a bidirectional relationship, meaning one can worsen the other