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Studies have shown that several DNMT inhibitors including azacitidine, decitabine, procainamide, hydralazine, and epigallocatechin-3-gallate are applied in animals, which show excellent efficacies via decreasing pro-inflammatory cytokines ( i.e

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Zinc and B12 deficiencies respond quickly to oral supplementation

The most common severe adverse events (grade 3 or 4) were hypertension, increased liver enzymes, hyponatremia, and diarrhea [34]

11 Advise patients to stop treatment if they have an acute gastrointestinal illness (and resume treatment once they have recovered)