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The efficacy of IDegLira (Insulin Degludec/Liraglutide combination) in adults with type 2 diabetes inadequately controlled with a GLP-1 receptor agonist and oral therapy: DUAL III randomized clinical trial

Using GLP-1 Receptor Agonists and Metformin Together Benefits of Combining Both Treatments Pairing GLP-1 receptor agonists with metformin delivers results that surpass using either medication alone

doi: 10.1177/1559325818761455 96 ErdivanliBOzdemirASenAMercantepeTKazdalHUyduHAet al

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However, despite encouraging early laboratory findings, its clinical development was discontinued in 2007 after failing to demonstrate significant weight-loss efficacy in large-scale human trials